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INTERNATIONAL JOURNAL OF INFORMATION TECHNOLOGY - Volume 8 Issue 11, Aug-Sep

Pages: 10-20
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HYDROCHALCONE COMPOUNDS FROM INDONESIAN MEDICINAL PLANT, “SIRIH HUTAN”, Piper aduncum

Author: R. Kartika1, *, Sudrajat1 , Bustanussalam2 and P. Simanjuntak

Category: Medicinal Article

Abstract:

Isolation, purification and identification of two hydrochalcone compounds from Indonesian medicinal plant “Sirihhutan”, Piper aduncum (Piperaceae) had been done. Isolation and purification of ethylacetate extract subjected to column chromatography (SiO2; (i).n-hexane-ethylacetate = 10:1 ~ 1 : 1; ethylacetate (ii).n-hexaneethylacetate = 8: 1 gave two pure compounds. Based on infra red, 1D & 2D-NMR, mass spectral data and comparison chemical shift of protons and carbons, the isolated compounds are 2’,6’-dihydroxy-4’-methoxy dihydrochalcone and 2’,6’,4-trihydroxy-4’-methoxy dihydrochalcone with free radical scavenging inhibitionvalues are 21.77 % and 90.1 % respectively.

Keywords: Hydrochalcone; Piper aduncum; Piperaceae; 2’, 6’-dihydroxy-4’-methoxy dihydrochalcone; 2’, 6’, 4- trihydroxy-4’-methoxy dihydrochalcone

DOI: 10.31788/RJC.2019.1235186

DOI URL: http://dx.doi.org/10.31788/RJC.2019.1235186

Full Text:

This research is a continuation of chemical studies on Indonesian medicinal plants, especially on bioactive chemical compounds as antioxidant.1-5 This research focused on hydrochalcone compounds from“SirihHutan” (localname), Piper aduncum L.(Piperaceae). Traditionally, this plant isused as a deodorant, antihaemorraghea, antivomit, anti-septic, antibacterial and antifungi6 . Based on the literature, this plant has activities as antibacteria6 , insectiside7 , andantioxidant8 . Isolation results of antioxidant bioactive compounds from ethylacetate fraction of P.aduncum L based on free radicals cavenging activity test usingDPPH (1,1-diphenylpycrilhidrazine) gave two hydrochalcone compounds, i.e.2’,6’-dihydroxy-4’-methoxy dihydrochalcone and 2’,6’,4-trihydroxy-4’-methoxy dihydrochalcone.

References:

1. R. Kartika, T. Barus, R. Surbakti, and P. Simanjuntak, Asian J. of Chem., 26(18),6047(2014), DOI: 10.14233/ajchem.2018.20935 2. B. Ginting, L. Marpaung, T. Barus, and P. Simanjuntak, Asian J. of Chem., 28(1),199(2016), DOI: 10.14233/ajchem.2016.19541. 3. M. Simorangkir, T. Barus, R. Surbakti, and P. Simanjuntak, Asian J. of Chem., 28(1),203(2016), DOI: 10.14233/ajchem.2016.19541 4. H. brSembiring, T. Barus, L. Marpaung and P. Simanjuntak, Asian J. of Chem., 29(8), 1743(2017), DOI: 10.14233/ajchem.2017. 20363. 5. Mastura, T. Barus, L. Marpaung and P. Simanjuntak, Asian J. of Chem., 30(4), 84(2018), DOI: 10.14233/ajchem.2018. 20935. 6. T. Matsuda, A. Inazumi, Y. Yamada, W.G. Padolina, H. Kikizaki, and N. Nakatani, Phytochem., 20(10), 3227(1991). 7. M. Scott, H. R. Jensen, B.J.R. Philogene, J.T. Arnason, Phytochem. Rev., 7, 65(2008), DOI: 10.1007/S 11101-006 9058.5 8. C. Masuoka, M. Ono, Y. Ito and T. Nohara, Food Sci. Technol. Int. Tokyo, 3(3),285(1997) 9. R. Li, J. Yang, Y. Wang, Q. Sun, and H. H, Nat. Prod. Comm., 9(7),1011(2014) [RJC