<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>developer</PublisherName> <JournalTitle>International journal of Information Technology</JournalTitle> <PISSN/> <EISSN>n</EISSN> <Volume-Issue>Volume 40 issue 1</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>2021</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Subject-1</ArticleType> <ArticleTitle>Is Gene polymorphism of Advance Glycation End Product receptors related to severity of neuropathy among Iraqi type ?? diabetic patients: Case control study</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>490</FirstPage> <LastPage>499</LastPage> <AuthorList> <Author> <FirstName>Hawraa S. Aljubawi1</FirstName> <LastName/> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Hayder K. Hassoun2</FirstName> <LastName/> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Sami R.</FirstName> <LastName>Alkatib3</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>Objective: To detect any correlation between rs1800624 (374 A/T) RAGE gene polymorphism with the development and/or severity of diabetic peripheral neuropathy. Patients and method: The cross sectional case controlled study include 149 type 2 diabetic patients, patients recruited from diabetic center in Marjan medical city and from diabetic center in Al-Sadr medical city in the Middle Euphoarates area of Iraq during the period from June 2019 to April 2020 .The patients is divided into 2 group according to clinical finding and results of neurophysiologic studies; group I with diabetic neuropathy (DNP) and group II without neuropathy. Genetic study using polymerase chain reaction (PCR) and Restriction fragment length polymorphism (RFLP) were done for all participants looking for RAGE (receptor of advanced glycation end products) gene by determining RAGE gene rs1800624 polymorphism for both groups. Results: The three genotypes of RAGE gene, AA (wild-type) and the two RAGE rs1800624 polymorphic genotypes (AT and TT) were analyzed for both groups. Majority with DPN group (72.4 %) carry the wild type gene (AA). Heterozygous polymorphic RAGE gene (AT) was present in (55 %) of patients with DPN, homozygous RAGE gene polymorphisms(TT) were also more common in patients with DPN (29%).The study found significant association of TT genotype and severity of DNP.TT genotype was dominant in 63% of patients with severe DNP, while TT genotype was observed only in 17.6% of patients with mild and in 19.1% of patients with moderate peripheral neuropathy. Conclusions: There was significant association between rs1800624 (374 A/T) RAGE gene polymorphism and with occurrence and/or severity of diabetic peripheral neuropathy.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Receptors, advanced glycation end products, gene polymorphism, diabetic peripheral neuropathy</Keywords> <URLs> <Abstract>https://developer.ubipayroll.com/ubijournal-v1copy/journals/abstract.php?article_id=13129&title=Is Gene polymorphism of Advance Glycation End Product receptors related to severity of neuropathy among Iraqi type ?? diabetic patients: Case control study</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>1. Davidsons. (2018).Diabetes mellitus: Principles and Practice of Medicine,23th edit. 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