<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>developer</PublisherName> <JournalTitle>International journal of Information Technology</JournalTitle> <PISSN/> <EISSN>n</EISSN> <Volume-Issue>volume 8 issue8</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>may-june 2019</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>2019</Year> <Month>06</Month> <Day>21</Day> </PubDate> <ArticleType>Research</ArticleType> <ArticleTitle>TOXICITY AND ANTIOXIDANT ACTIVITIES OF EXTRACT OF n-HEXANE, H2O, AND ETHYL ACETATE FROM THE LEAVES OF DURIAN, Durio zibethinus L.</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>947</FirstPage> <LastPage>950</LastPage> <AuthorList> <Author> <FirstName>Dyna Grace Romatua</FirstName> <LastName>Aruan</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Tonel</FirstName> <LastName>Barus</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Ginda</FirstName> <LastName>Haro</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Partomuan</FirstName> <LastName>Simanjuntak</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI>10.31788/RJC.2019.1225204 </DOI> <Abstract>Steroids are secondary metabolites abundantly found in plants. Traditionally, the leaves of durian, Durio zibethinus L. (Malvaceae) have been used as an antipyretic and analgesic by communities in Indonesia. This research was performed to discover the potency of some extracts from the leaves of D. zibethinus L. as antioxidants and investigate their toxicity. The extracts of durian leaves, D. zibethinus L. was carried out with 96% ethanol, then partitioned with water, n-hexane, and ethyl acetate respectively. The antioxidant and toxicity screening was done by Brine Shrimp Lethality Test (BSLT) and free radical scavenging method using diphenyl-1-picylhydrazyl (DPPH). Brine shrimp lethality test (BSLT) gave a toxicity LC50 of 195.13; 85.37; and 453.78 ppm for n-hexane, ethyl acetate and water extracts, respectively. Free radical scavenging method using diphenyl-1-picrylhydrazyl gave an antioxidant activity IC50 90.58; 48.04; and 171.78 ppm for water, n-hexane, and ethyl acetate extracts, respectively. Result of the studies paves the way for further studies on isolation and characterization of the chemical compound as antioxidant and anticancer.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Toxicity, Antioxidant, Steroids, Durio zibethinus L., Malvaceae</Keywords> <URLs> <Abstract>https://developer.ubipayroll.com/ubijournal-v1copy/journals/abstract.php?article_id=6242&title=TOXICITY AND ANTIOXIDANT ACTIVITIES OF EXTRACT OF n-HEXANE, H2O, AND ETHYL ACETATE FROM THE LEAVES OF DURIAN, Durio zibethinus L.</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>REFERENCES 1. S. Kitamura, Transport of Flavonoids, 2006. From Cytosolic Synthesis to Vacuolar Accumulation, In Grotewold, E., At The Science of Flavonoids. The Ohio State University Columbus, Ohio, USA, DOI:10.1007/978-0-387-28822-2 2. F. Toledo, P. A. Avila, International Journal of Food Sciences and Nutrition, 59, 5 (2008). DOI:10.1080/09637480701603082 3. Y. Liu, S. Feng, L. Song, G. He, M. Chen, D. Huang, Secondary Metabolites in Durian Seeds; Oligomeric Proanthocyanidins, p.18 (2013), DOI: 10.3390/molecules181114172 4. M. Insanu, Natural Anthraquinone from The Bark of Chincona officinalis L., 12(2), 519(2019), DOI: 10.31788/RJC.2019.1221831 5. B. N. Meyer, Planta Medica., 45, 31(1982), DOI: 10.1055/s-2007-971236 6. P. Molyneux, J. Sci. Technol., 26(2), 211(2004) 7. D. G. R. Aruan, T. Barus, Phytochemical Screeening and Antidiabetic Activity of N Hexane, Ethyl Acetate and Water Extract From Durian Leaves (Durio zibethinus L.), 35(1), 487-(2019), DOI: 10.13005/ojc/350166 8. P.S. Widyawati, T. D. W. Budianta, F. A. Kusuma, and E. L. Wijaya, Intern. J. of Pharmcog. And Phytochem. Res., 6(4), 850(2014)</References> </References> </Journal> </Article> </ArticleSet>