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  <Article>
    <Journal>
      <PublisherName>developer</PublisherName>
      <JournalTitle>International journal of Information Technology</JournalTitle>
      <PISSN/>
      <EISSN>n</EISSN>
      <Volume-Issue>Volume 8 Issue 11</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>Aug-Sep</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2019</Year>
        <Month>08</Month>
        <Day>2</Day>
      </PubDate>
      <ArticleType>Medicinal Article</ArticleType>
      <ArticleTitle>A SPECTROSCOPIC EVIDENCE FOR REACTIVE OXYGEN SPECIES PRODUCTION BY L-TRYPTOPHAN PHOTO OXIDATION FOR PGSA DENDRIMER-PROTOPORPHYRIN IX NANOFORMULATION</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>10</FirstPage>
      <LastPage>20</LastPage>
      <AuthorList>
        <Author>
          <FirstName>M. Suresh</FirstName>
          <LastName>Kumar1</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>2</FirstName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>*</FirstName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>P. Aruna1  and S.</FirstName>
          <LastName>Ganesan1</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI>10.31788/RJC.2019.1235149 </DOI>
      <Abstract>Photodynamic therapy is an emerging modality for cancer treatment which involves the uptake of photosensitizer by cancer tissues followed by photo irradiation. Based upon the action of light activated photosensitizer in the excited state with the molecular oxygen, Reactive oxygen species (ROS) or free radicals formed due to electron transfer or energy transfer process are very toxic to cancer cells that can react with biomolecules and causes cell death. The present study describes the spectroscopic method of identification of ROS production for a model photosensitizer (PS), protoporphyrin IX (PpIX) in free and after loaded inside the biocompatible dendrimeric nano carrier with the help of decrease in tryptophan emission intensity at 286nm excitation. The photochemical reaction of L-tryptophan with ROS after light treatment indicates, this may be due to photo-oxidation of tryptophan. This information supports to explore our study as spectroscopic evidence for monitoring the ROS production during photodynamic therapy.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Photodynamic therapy, biocompatible anionic dendrimer, Reactive oxygen species, Protoporphyrin IX, Tryptophan, cancer, spectroscopy.</Keywords>
      <URLs>
        <Abstract>https://developer.ubipayroll.com/ubijournal-v1copy/journals/abstract.php?article_id=6321&amp;title=A SPECTROSCOPIC EVIDENCE FOR REACTIVE OXYGEN SPECIES PRODUCTION BY L-TRYPTOPHAN PHOTO OXIDATION FOR PGSA DENDRIMER-PROTOPORPHYRIN IX NANOFORMULATION</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>1. I. Postiglione, A. Chiaviello and G. Palumbo, Cancers, 3(2), 2597(2011), DOI: 10.3390/cancers3022597. 2. G. Manda, M.T. Nechifor and T.M. Neagu, Curr. Chem. Biol., 3(1), 342(2009), DOI: 10.2174/2212796810903010022. 3. G.S. Mohammed Omar, Ph. D. Thesis, University College London, United Kingdom (2010). 4. P.M.L.R. Juliana, A.S.M. Mary, F.G. Sara, B.A. Fernando, R.S. Jackson, A.P.N. Nadia, C.J.Z. Iriana and K.A.R. Lidiyani, Photochemistry and Photobiology. B, Biology, 106, 40(2012), DOI: 10.1016/j.jphotobiol.2011.10.001 5. E. Shacter, Drug Metabolism Review, 32(3-4), 307(2000), DOI: 10.1081/DMR-100102336 6. C.R. Maria and J.C. Robert, Coordination Chemistry Reviews, 233-234, 351(2002), DOI: 10.1016/S0010-8545(02)00034-6. 7. A. Milzani, R. Rossi, P. Di Simplicio, D. Giustarini, R. Colombo, I. Dallendonne, Protein Science, 9(9), 1774(2000), DOI: 10.1110/ps.9.9.1774. 8. Fathi Awad, C. Ramprasath, S. Sivabalan, N. Mathivanan, P. Aruna and S. Ganesan, African Journal of Microbiology Research, 7(37), 4617(2013), DOI: 10.5897/2013.5885. 9. M. Suresh Kumar, B. Anish, R. Murugesan and K. Jeyasubramanian, Nano Biomed. Eng., 4(3), 132(2012), DOI: 10.5101/nbe.v4i3.p132-138.</References>
      </References>
    </Journal>
  </Article>
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